منابع مشابه
Neutron crystallography – Then and now *
Neutron crystallography began to be employed at the Bhabha Atomic Research Centre (BARC), Trombay, Mumbai in the early sixties. At that time, the technique, at BARC as well as elsewhere, was in a nascent state, with emphasis on building of instruments and development of crystallography software. Over the years, the Trombay group kept pace with the advancements in other parts of world and employ...
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Synchrotron radiation (SR) techniques are continuously pushing the frontiers of wavelength range usage, smaller crystal sample size, larger protein molecular weight and complexity, as well as better diffraction resolution. The new research specialism of probing functional states directly in crystals, via time-resolved Laue and freeze trapping structural studies, has been developed, with a range...
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The Protein Crystallography Station at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. This capability also includes the Macromolecular Neutron Crystallography (MNC) consortium between Los Alamos (LANL) and Lawrence Berkeley National Laboratories for developing computational too...
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Since drugs bind to their targets through directional H bonding and non-directional hydrophobic and electrostatic interactions, neutron crystallography can help guide structure-based drug design. This is illustrated by McKenna and co-workers [Aggarwal et al. (2016), IUCrJ, 3, 319-325] who describe the room-temperature neutron structure of human carbonic anyhydrase II in complex with the clinica...
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ژورنال
عنوان ژورنال: hamon
سال: 2013
ISSN: 1349-046X,1884-636X
DOI: 10.5611/hamon.23.1_81